After a mysterious plague devastates the global male population, Yorick Brown is the last man left alive. Yorick's quest to find his missing fiancee takes him to Australia, a country devastated by cheap drugs. When an incredulous journalist looking for the ultimate scoop discovers his existence, she plans to expose him to the female world.

After a mysterious plague devastates the global male population, Yorick Brown is the last man left alive. His mother is the President, his only friend a monkey called Ampersand and his survival in this hostile new world is constantly in question! Yorick's quest to find his missing fiancee Beth takes him to Australia, a country now devastated by an influx of cheap drugs. When an incredulous journalist looking for the ultimate scoop discovers his existence, she plans to expose him to the female world, no matter what the cost! Superstar creators Brian K. Vaughan (Ex Machina) and Pia Guerra continue the ground-breaking series that has taken the comics world by storm!