Presents approaches to immune regulation of human pathogens and vaccine development by an international group of basic and clinical researchers from government, academia and industry who are interested either in the molecular mechanisms of microbial pathogenesis or in human immune response.

This volume presents clear approaches to immune regulation of human pathogens and vaccine development. The book brings together the work of an international group of basic and clinical researchers from government, academia and industry who are interested either in the molecular mechanisms of microbial pathogenesis or in human immune response. The overall emphasis of this volume is to identify effective and efficient strategies for harnessing immunologic approaches to infectious disease. The material comprises the proceedings of a conference held in New York on 8-11 September 1993.

Part 1 Evasion of Host Defence: Structure and Function of the Parasitophorous Vacuole Membrane Surrounding "Toxoplasma gondii", K.A. Joiner et al
Serum Resistance of "Neisseria gonnorhoeae" - Does it Thwart the Inflammatory Response and Facilitate the Transmission of Infection?, P.A. Rice et al
The Cell Biology of "Listeria monocytogenes" Infection (Escape From a Vacuole), D.A. Portnoy and S. Jones
Identification of Genes Involved in the Resistance of Mycobacteria to Killing by Macrophages, S. Mundayoor and T.M. Shinnick. Part 2 Microbial Virulence Factors and Antigenic Variation: Mechanisms and Strategies of Viral Antigenic Variation, T.M. Folks
Regulation of Cytokine Patterns in Leprosy, P.A. Sieling and R.L. Modlin
Role of Alpha/Beta T and Gamma/Delta Cells in Innate and Acquired Immunity, H.K. Ziegler et al. Part 3 Host Response to Microbial Invasion: New Perspectives on Use of Thymic Factors in Immune Deficiency, Susanna Cunningham-Rundles et al
Interaction Between the Innate and the Acquired Immune System Following Infection of Different Mouse Strains with "Leishmania major", P. Scott and Tanya Scharton
Modification of Amphotericin B's Therapeutic Index by Increasing its Association with Serum High-density Lipoproteins, K.M. Wasan and G. Lopez-Berestein
Induction of Protective Immunity Using Minigenes, J.L. Whitton. Part 4 Cytokines in Microbial Pathogenesis: An Evolutionary and Functional Approach to the TNF Receptor Ligand Family, B. Beutler and C. Van Huffel
The Role of Interleukin-8 in the Infectious Process, S.L. Kinkel et al
The Development of Effective Vaccine Adjuvants Employing Natural Regulators of T-Cell Lymphokine Production "In Vivo", R.A. Daynes and Barbara A. Araneo. Part 5 Attachment, Adherence and Host Receptors - Mechanism of Cell and Tissue Injury: Bacterial Adherence and Mucosal Cytokine Production, C. Svanborg et al
Interaction of Pathogenic "Neisseria" with Host Defences - What Happens "In Vivo"?, R.F. Rest et al
Molecular and Cellular Mechanisms of Tissue Invasion by "Shigella flexneri", A. Zychlinsky et al. Part 6 Recent Developments in Vaccination and Immunoprophylaxis: Antiidiotype Antibodies as Surrogates for Polysaccharide Vaccines, M.A. Julie Westerlink et al
Oral Vaccine Models - Multiple Delivery Systems Employing Tetanus Toxoid, R.J. Jackson et al
Clinical Use of Hematopoietic Growth Factors for Control of Infections After High-dose Chemotherapy, J.M. Felser. Part 7 Poster papers.