Liver Metastasis
Biology and Clinical Management

Despite recent advances in surgery, and more aggressive resection, liver metastases still prove fatal in a high proportion of cases. This volume aims to enhance our understanding of the biology of hepatic cancer metastasis, in particular its early stages.

By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.

BIOLOGY. 1.
Cellular and molecular aspects of the liver architecture and function. 2.
The tumor microenvironment at different stage of hepatic metastasis. 3.
The Colorectal Cancer Initiating Cell: Markers and their role of in liver metastasis. 4.
Role of CXC chemokines and receptors in liver metastasis -- impact on liver resection-induced engraftment and tumor growth. 5.
Role of Inflammation in the early stages of liver metastasis. 6.
Signal transduction in tumor-endothelial cell communication. 7. Tumor dormancy in liver metastasis: clinical and experimental evidence and implications for treatment. 8. Role of the IGF- axis in liver metastasis: experimental and clinical evidence. 9. Breast Cancer Liver Metastasis. CLINICAL MANAGEMENT.10.
Imaging of Hepatic Metastases. 11.
Colorectal Carcinoma Liver Metastasis: Surgical Clinical Perspective. 12. Evaluation and Management of Liver Metastases from Non-Gastrointestinal Cancer. 13. Proteomic profiling of hepatic metastases: Paving the way to individualized therapy. 14. Targeting Angiogenesis in the Treatment of Hepatic Metastasis. 15.
Uveal melanoma -- a paradigm of site-specific liver metastasis.