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Inclusion-Body Myositis and Myopathies


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Word Power Books

Inclusion-Body Myositis and Myopathies

W. King Engel (Editor)
Valerie Askanas (Editor)
Georges Serratrice (Editor)



ISBN: 9780521571050


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This book is devoted entirely to discussing the two forms of inclusion-body myositis.

Inclusion-body myositis (IBM) is now understood to be an important degenerative muscle disease. The sporadic type (s-IBM) is probably the most common muscle disease among those ailments that strike first in adulthood (particularly people over 50). The hereditary type (h-IBM) affects younger patients. This book is devoted entirely to both s-IBM and h-IBM. Contributors discuss what is understood about the basic scientific foundations of IBMs, the varied aspects of the pathology of IBMs, and the application of clinical treatments. One particular emphasis of the book is on the hereditary aspects of IBM and genetic predispositions to the disease. This comprehensive review should greatly interest those involved with research and treatment of neuromuscular disease, especially those in neurology, rheumatology, and physical medicine.


ISBN 521571057
ISBN13 9780521571050
Publisher Cambridge University Press
Format Hardback
Publication date 13/04/1998
Pages 413
Weight (grammes) 720
Published in United Kingdom
Height (mm) 228
Width (mm) 152

Part I. Overview of Pathologic and Pathogenic Comparison Between Sporadic Inclusion-Body Myositis and Hereditary Inclusion-Body Myopathies: 1. Newest approaches to diagnosis and pathogenesis of sporadic inclusion-body myositis and hereditary inclusion-body myopathies, including molecular-pathologic similarities to Alzheimer disease
Part II. Historical Perspective: 2: Evolving concepts of inclusion-body myositis
Part III. Sporadic Inclusion-Body Myositis - Clinical and Diagnostic Considerations: 3: Sporadic inclusion-body myositis: Clinical and laboratory features and diagnostic criteria
4: Inclusion-body myositis: natural history
5: Uncommon clinico-pathological forms of sporadic inclusion-body myositis: Report of four cases
6: Inclusion-body myositis: pathological changes
7: Unusual pathological forms of inclusion-body myositis, and neuromuscular disorders with IBM-like changes
8: Electrophysiological findings in inclusion-body myositis
9: Genetic factors in sporadic inclusion-body myositis
Part IV. Hereditary Inclusion-Body Myopathies - Clinical and Diagnostic Considerations: 10: Hereditary inclusion-body myopathy in Jews of Persian origin: Clinical and laboratory data
11. Hereditary inclusion-body myopathy (h-IBM) with quadriceps sparing: epidemiology and genetics
12: Familial autosomal-recessive inclusion-body myositis with asymptomatic leukoencephalopathy
13: Welander distal myopathy - clinical, pathophysiological, and molecular aspects
14. Tibial muscular dystrophy - clinical, genetic, and morphological characteristics
15. Distal myopathy with rimmed vacuoles, inclusion-body myositis and related disorders in Japan
16. Inclusion-body myopathies
17. Is the muscle fiber in inclusion body-myositis an antigen-presenting cell of an innocent bystander?
18. Viruses, immunodeficiency and inclusion-body myositis
19. Myonuclear abnormalities may play a central role in the pathogenesis of muscle fiber damage in inclusion-body myositis
20. Nuclear degeneration and rimmed vacuole formation in neuromuscular disorders
21. Mitochondrial alterations in sporadic inclusion-body myositis
22. mtDNA analysis in muscle of patients with sporadic inclusion-body myopathy
Part V. Treatment: 23. Evaluation of treatment for sporadic inclusion-body myositis
24. Personal experience in treating sporadic inclusion-body myositis
Subject index.