Cell Transplantation for Neurological Disorders

Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

The Lund Transplant Program for Parkinson's Disease and Patients with MPTP-Induced Parkinsonism, Hakan Widner. Fetal Nigral Transplantation in Parkinson's Disease: The USF Pilot Program (12- to 24-Month Evaluation), Robert A. Hauser, C. Warren Olanow, Barry J. Snow, and Thomas B. Freeman. Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson's Disease, Mark Peschanski, Gilles Defer, Sophie Dethy, Philippe Hantraye, Marc Levivier, Jean-Paul Nguyen, and Pierre Cesaro. PET Studies of Transplantation Therapy,Barry J. Snow. Neuropathology of Dopaminergic Transplants in Patients with Parkinson's Disease, Jeffrey H. Kordower, Rose Hanbury, and Krzysztof S. Bankiewicz. Fetal-Tissue Transplantation for Huntington's Disease, Paul R. Sanberg, Cesario V. Borlongan, Klas Wictorin, and Ole Isacson. Fetal Transplantation in Huntington's Disease,O. V. Kopyov, S. Jacques, M. Kurth, L. Philpott, A. Lee, M. Patterson, C. Duma, A. Lieberman, and K. S. Eagle. Topographic Factors Affecting the Functional Viability of Dopamine-Rich Grafts in the Neostriatum
Stephen B. Dunnett and Barry J. Everitt .Immunological Issues in Rodent and Primate Transplants (Allografts), Hakan Widner. Transplanting Fetal Neural Xenogeneic Cells in Parkinson's and Huntington's Disease Models, Ole Isacson, Peyman Pakzaban, and Wendy R. Galpern. Animal Models of Cerebral Ischemia: Neurodegeneration and Cell Transplantation, Cesario V. Borlongan, Toru Shimizu, John Q. Trojanowski, Shigeru Watanabe, Virginia M.-Y. Lee, Yasuo Tajima, David W. Cahill, Thomas B. Freeman, Hitoo Nishino, and Paul R. Sanberg. Transplantation Strategies for the Treatment of Pain, Jacqueline Sagen. Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells, Dwaine Emerich, Mark D. Lindner, Joel Saydoff,
and Frank T. Gentile. Transplant Strategies in Myelin Disorders, Ian D. Duncan. Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases,Silke Thode, Heather K. Raymon, and Fred H. Gage. Adequately Respecting and Protecting Fetal Tissue Donors and Their Next-of-Kin, Dorothy E. Vawter and Karen G. Gervais. Index.