Brain Injury

Part of the "Molecular and Cellular Biology of Critical Care Medicine" series, this volume addresses the molecular and cellular basis of acute brain injury. It covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke.

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Foreword. Preface. Contributors. 1. Excitotoxic Damage
in Traumatic Brain Injury
O.L. Alves, R. Bullock.
2. The Multifaceted Role of Adenosine in Experimental and
Clinical Traumatic Brain Injury
P.M. Kochanek, E.K.
Jackson. 3. Preconditioning
M.J. Bell, J.M.
Hallenbeck. 4. Molecular and Cellular Mechanisms of
Traumatic Cerebral Vascular Injury
D.S. DeWitt, D.S. Prough.
5. Inflammatory Response to Brain Injury
M.C.
Morganti-Kossmann, M. Rancan, P.F. Stahel, V.I. Otto, T.
Kossmann. 6. Free Radicals and Acute Brain Injury: Mechanisms
of Oxidative Stress and Therapeutic Potentials
H. Bayir, V.E.
Kagan. 7. Mitochondria in Acute Brain Injury
Y.Y. Han,
I.J. Reynolds. 8. Cell Signaling: Serine/Threonine Protein
Kinases and Traumatic Brain Injury
L. Jenkins, C.E. Dixon, G.
Peters, Wei-Min Gao, Xiaopeng Zhang, P.D. Adelson, P.M.
Kochganek. 9. Death Receptors in Acute Brain Injury
M.J.
Whalen, M.A. Moskowitz. 10. Apoptosis
Xiaopeng Zhang,
M.A. Satchell, R.S.B. Clark, P.D. nathaniel, P.M. Kochaenek,
S.H. Graham. 11. Ischemia-Induced Ionic Mechanisms of
Injury in the Developing Brain
R.C. Tasker. 12.
Neurocytoskeletal Changes Following Traumatic Brain Injury
J.W.
Huh, T.K. McIntosh, M.A. Helfaer, K.E. Saatman. 13.
Neurotransmitter and Growth Factor Alterations in Functional Deficits
and Recovery Following Traumatic Brain Injury
A.E. Kline, L.W.
Jenkins, Hong Q. Yan, C.E. Dixon. 14. Reproductive Hormones
as Neuroprotectants in Brain Injury
N.J. Alkayed, M.M. Wang,
P.D. Hurn. 15. Role of Genetic Background: Influence of
Apolipoprotein E Genotype in Alzheimer's Disease and After Head
Injury
M.E. Kerr, S.T. DeKosky, A. Kay, D.W. Marion.
16. Anesthetics and the Injured Brain
D.S. Warner. Index.