Summarizes understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complications. This book examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications. It emphasizes the potential synergistic effects of an interlinked antioxidant network.

This book emphasizes the potential synergistic effects of an interlinked antioxidant network, investigates the controversy surrounding the significance of oxidative stress markers in diabetes, highlights oxidative stress and antioxidant treatment in animal models for juvenile and adult onset diabetes, explores the hypothesis that ischemic reperfusion is the primary cause of diabetic polyneuropathy, links protein kinase C activation to the development of diabetic vascular complications and the effectiveness of vitamin E in preventing these abnormalities, and spotlights recent clinical trials of therapeutic effects of antioxidants to reduce insulin resistance, and much more! Illustrating the therapeutic potential of antioxidants for the treatment of diabetes, "Antioxidants in Diabetes Management" is an unparalleled reference for endocrinologists, nutritionists and dietitians, cell biologists and biochemists, cardiologists, pathologists, and graduate and medical school students in these disciplines.

Oxidative Stress and Antioxidants: The Antioxidant Network, -Lipoic Acid, and DiabetesLester PackerOxidative Stress in Diabetes: Why Does Hyperglycemia Induce the Formation of Reactive Oxygen Species?Peter R/sen, Xue Liang Du, and Guang-Zhi SuiOxidative Stress Markers in Human Disease: Application to Diabetes and to Evaluation of the Effects of AntioxidantsBarry HalliwellPlasma Lipid Hydroperoxide and Vitamin E Profiles in Patients with Diabetes MellitusJaffar Nourooz-ZadehConcentrations of Antioxidative Vitamins in Plasma and LDL of Diabetic PatientsWolfgang LeonhardtOxidative Stress in DiabetesJohn W. Baynes and Suzanne R. ThorpeAntioxidative Defense in Diabetic Peripheral Nerve: Effects of DL- -Lipoic Acid, Aldose Reductase Inhibitor and Sorbitol Dehydrogenase InhibitorIrina G. Obrosova, Douglas A. Greene, and Hans-Jochen LangPathways of Glucose-Mediated Oxidative Stress in Diabetic NeuropathyDouglas A. Greene, Irina G. Obrosova, Martin J. Stevens, and Eva L. FeldmanExperimental Diabetic Neuropathy: Oxidative Stress and Antioxidant TherapyHans J. Tritschler, James D. Schmelzer, Yutaka Kishi, Yoshiyuki Mitsui, Masaaki Nagamatsu, Kim K. Nickander, Paula J. Zollman, and Phillip A. LowAntioxidants in the Treatment of Diabetic Polyneuropathy: Synergy with Essential Fatty AcidsNorman E. Cameron and Mary A. CotterA Thioctic Acid-Gamma-Linolenic Acid
Conjugate Protects Neurotrophic Support in Experimental Diabetic NeuropathyLuke Hounsom and David R. TomlinsonClinical Trials of -Lipoic Acid in Diabetic Polyneuropathy and Cardiac Autonomic NeuropathyDan ZieglerOxidative Stress, NF-kB Activation, and Late Diabetic ComplicationsPeter P. Nawroth, Valentin Borcea, Angelika Bierhaus, Martina Joswig, Stephan Schiekofer, and Hans J. TritschlerMolecular Basis of -Tocopherol Action and Its Protective Role Against Diabetic ComplicationsAngelo Azzi, Roberta Ricciarelli, Sophie Cl?ment, and Nesrin zerProtein Kinase C Activation, the Development of Diabetic Vascular Complications, and the Role of Vitamin E in Preventing These AbnormalitiesSven-Erik Bursell and George L. KingOxidative Stress and Pancreatic -Cell Destruction in Insulin-Dependent Diabetes MellitusMizuo Hotta, Eiji Yamato, and Jun-ichi MiyazakiInterrelationship Between Oxidative Stress and Insulin ResistanceKaren Yaworsky, Romel Somwar, and Amira KlipOxidative Stress and Antixodant Treatment: Effects on Muscle Glucose Transport in Animal Models of Type 1 and Type 2 DiabetesErik J. HenriksenOxidative Stress and Insulin Action: A Role for Antioxidants?Stephan Jacob, Rainer Lehmann, Kristian Rett, and Hans Ulrich-H?ring