Angiogenesis and Direct Myocardial Revascularization

Presents a review of the basic, preclinical, clinical, and developmental pathways to treatment strategies, such as therapeutic angiogenesis and myogenesis. This book covers the identification of therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, and others.

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

No-Option Patients: A Growing Problem
Roger J. Laham and Donald S. Baim

Transcriptional Regulation of Angiogenesis
Peter Oettgen

Preclinical Models and Experience to Date
Aysegul Yegin and Nicolas A. Chronos

The Coronary Microcirculation and Angiogenesis
Pierre Voisine, David G. Harrison, and Frank W. Sellke

Local and Regional Vascular Delivery for Therapeutic Angiogenesis and Myogenesis
Erik T. Price, Alan C. Yeung, and Mehrdad Rezaee

Imaging Angiogenesis: A Guide for Clinical Management and Therapeutic Trials
Justin D. Pearlman

Myocardial Angiogenesis: Protein Growth Factors
Kwang Soo Cha, Robert S. Schwartz, and Timothy D. Henry

Gene Therapy for Angiogenesis in the Treatment of Cardiovascular and Peripheral Arterial Disease
Pinak B. Shah, Kapildeo Lotun, and Douglas W. Losordo

Therapeutic Angiogenesis in Peripheral Arterial Disease: Current Approaches and Future Directions
Richard E. Waters and Brian H. Annex

Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis
Hung-Fat Tse, Pui-Yin Lee, and Chu-Pak Lau

Transplantation of Embryonic Stem Cells for Myocardial Regeneration and Angiogenesis
Yong-Fu Xiao, Jiang-Yong Min, and James P. Morgan

Skeletal Myoblast Transplantation for Cardiac Repair
Audrey Rosinberg, Jamal S. Rana, and Roger J. Laham

Transmyocardial Laser Revascularization
Keith A. Horvath

Index