This text contains the refresher course lectures of the 1999 meeting, and provides a review of the state of the art in anesthesia clinical pharmacology. It features sections on pharmacology concepts, drug delivery techniques, the latest drugs, and novel thinking about older drugs.

This text contains the refresher course lectures of the 1999 meeting, and provides a review of the state of the art in anesthesia clinical pharmacology. The authors of the individual chapters are recognized experts in the pharmacology of perioperative medicine. The book features sections on pharmacology concepts, drug delivery techniques, the latest drugs, and novel thinking about older drugs. It also addresses several areas that have emerged as very hot clinical and research topics, including depth of anesthesia monitoring technology and anesthesia drug interactions.

Preface. List of Contributors. New Pharmacokinetic Concepts
P.S.A. Glass. The Biophase Concept
D.R. Stanski. Handedness in Anesthetic Pharmacology
T.D. Egan. Anesthetics and Ventilatory Drive
P.L. Bailey. When does the Infant Mature Pharmacologically
D.M. Fisher. Brain Imaging for Elucidating Mechanisms of Anesthesia
P. Fiset. Is Pharmacokinetics Relevant? D.M. Fisher. Physiologic vs. Pharmacologic Sleep
P. Fiset. Awareness under Anesthesia: Current Understanding
P.S. Sebel. Depth of Anesthesia Monitoring Techniques: an Overview
D.R. Stanski. Bispectral Index Monitoring Technology: an Overview
C.E. Rosow. Bispectral Monitoring Technology: Clinical Applications
P.S. Sebel. Target Controlled Drug Delivery in Anesthesiology
S.E. Kern. The Principles of Total Intravenous Anesthesia (TIV A)
P.S.A. Glass. Transmucosal and Other New Drug Delivery Technologies
Th.H. Stanley. A Concept for Assessing Anesthetic Interactions
I. Kissin. Drug Interactions: Opioids and Sedative Hypnotics
C. Rosow. Interactions: General Principles
I. Kissin. Drug Interactions: Opioids and Inhaled Anesthetics
P.S.A. Glass. An Update on the Clinical Use of Propofol
P.F. White. Kinetic Considerations in the Selection of an Inhaled Anesthetic
E.I. Eger II. Controversies Regarding Sevoflurane &
Desflurane Toxicity
E.I. Eger II. The Role of Alpha2 Agonists in Anesthesiology
M. Maze. Current Concepts in Anti-Emetic Therapy, P.F. White. New Insights Into Muscle Relaxants
D.M. Fisher. Remifentanil: Clinical Applications
T.D. Egan. Drug Addiction Among Anesthesiologists
M. Maze. Antagonism of Anesthetic Effects
P. Fiset. Economics of Anesthesia Education
P.S. Sebel. The Role of Ketamine in Anesthetic Practice
P.F. White.