Analytical and Practical Aspects of Drug Testing in Hair

Offers coverage of some of the best hair drug testing techniques. This work reviews developments, the validation of analytical procedures, and the interpretation of data. It describes specific drugs, such as opiates, cocaine, and cannabis, and discuss the different testing methods of them.

The book also covers postmortem toxicology, pitfalls created by passive exposure, and testing for metals, including inductively coupled plasma spectrometry (ICP-MS), hair multielementary analysis, and the new speciation analysis. A complete, up-to-date resource that explains numerous drug testing techniques, "Analytical and Practical Aspects of Drug Testing in Hair" provides useful information for toxicologists, forensic scientists, sports medicine specialists, and pathologists.

DRUG INCORPORATION INTO HAIR Hair Physiology Drug Incorporation Routes Mechanisms of Binding General Discussion Concluding Remarks References PASSIVE EXPOSURE, DECONTAMINATION PROCEDURES, CUTOFFS, AND BIAS: PITFALLS IN THE INTERPRETATION OF HAIR ANALYSIS RESULTS FOR COCAINE USE Introduction
Historical Concerns for Passive Exposure in Hair Analysis Mechanisms for Incorporation of Drugs into Hair Drugs in the Environment Decontamination Procedures Cutoffs and Why They Matter Bias in Hair Testing Conclusions
Acknowledgments References OPIOIDS TESTING IN HAIR Introduction
Opiates Conclusions
References HAIR ANALYSIS FOR COCAINE Introduction
Analytical Methodologies Quality Control Interpretation of Results Acknowledgments Abbreviations
References DETERMINATION OF CANNABINOIDS IN HUMAN HAIR Introduction
Metabolism, Incorporation of Cannabinoids into Hair
Analytical Techniques for the Detection of Cannabinoids
Decontamination Processes Issues to Be Considered Criteria for Obtaining a Cannabis-Positive Hair-Test Result Controlled Studies: Empirical Data Analysis of a Large Sample of Hair Specimens
Reported Concentrations of Cannabinoids in Hair
Conclusions
References AMPHETAMINE DETERMINATION IN HAIR Introduction
Preamble Amphetamine Determination Conclusion References PHARMACEUTICALS IN HAIR Introduction
Discussion and Conclusion References SCREENING STRATEGIES IN HAIR ANALYSIS ON DRUGS Introduction
Immunochemical Screening in Hair Analysis Screening and Confirmation by GC-MS/MS
Multianalyte Screening Using LC-MS/MS Crime Cases Solved by Screening Hair Using LC-MS/MS
Conclusions
References CLINICAL APPLICATIONS OF HAIR ANALYSIS Introduction
Hair Analysis in Psychiatric Patients Hair Analysis in Epileptic Management Hair Analysis as Evidence of Prenatal and Postnatal Exposure to Drugs and Tobacco
Hair Nicotine as a Marker of Active and Passive Exposure to Tobacco Drug Addiction and Opiate-Maintenance Programs
Therapeutic Drug Monitoring References HAIR IN POSTMORTEM TOXICOLOGY Introduction
Methodological Aspects Strategies in Postmortem Work Conclusions and Take-Home Message
References DETECTION OF DOPING AGENTS IN HUMAN HAIR Introduction
Procedures Detection of Doping Agents Discussion
Conclusions
References APPLICATIONS OF HAIR IN DRUG-FACILITATED CRIME EVIDENCE
Introduction
Analytical Strategy Case Reports Discussion
Conclusion References APPLICATION OF HAIR IN DRIVING-LICENSE REGRANTING Introduction
Sensitivity of Drug Abuse Detection: Comparison between Urine and Hair Analysis
Hair Sampling for Drug Analysis Manipulation of Drug Concentrations in Hair
Hair Analysis for Regranting Driver's License Regulations in Other Countries
Conclusions
References ALCOHOL MARKERS IN HAIR General Problems in Detection of Chronic Alcohol Abuse
Fatty Acid Ethyl Esters (FAEE) Ethylglucuronide (EtG) Combined Use of FAEE and EtG Benzoylecgonine Ethyl Ester (Cocaethylene, BE-Et)
Further Possibilities Conclusions
References WORKPLACE DRUG TESTING USING HAIR SAMPLES Introduction
Sample Collection
Screening Procedures
Sample Preparation: Washing and Extraction Methods Confirmation by Mass Spectrometry Testing Body Hair Samples in Workplace Testing Conclusion References METALS Introduction
Hair Metal Incorporation
Hair Washing Procedure and Sample Preparation
Hair Elements Analytical Methods Metal Hair Reference Values
Hair Metal Analysis Interpretation
Hair Metal Analysis Results Metal Hair Certified Reference Material Elements Conclusion Acknowledgments References