This volume highlights major contributions that identify developments and directions in this field over the 1990s, as well as challenges for the foreseeable future. It offers an integration of information from laboratory and epidemiological studies, male reproduction and teratology.

This volume highlights major contributions that identify new developments and directions in the field over the past decade, as well as challenges for the foreseeable future. An integration of information from laboratory and epidemiological studies, male reproduction and teratology can be found throughout the volume. The range of topics include parental legacies and genomics, lifestyle, occupational and therapeutic paternal exposures and effects; effects on the gamete-packaging of human sperm; role of DNA repair and germ cell apoptosis; stem cells, epigenetics and closing; model systems and implications to clinicians and general counselors.

Preface. Sponsors. List of Participants. Gender-Specificity of Gamete Susceptibilities to Exposures. 1. Female-Specific Reproductive Toxicities Following Preconception Exposure to Xenobiotics
J.B. Bishop. 2. Overview of Male Mediated Developmental Toxicity
D. Anderson. Exposures and Effects: Occupational and Environmental. 3. Epidemiologic Evidence on Biological and Environmental Male Factors in Embryonic Loss
J.P. Bonde, et al. 4. Mechanisms of Male Mediated Developmental Toxicity Induced by Lead
E.K. Silbergeld, et al. 5. Paternal Exposure to Known Mutagens and Health of the Offspring: Ionizing Radiation and Tobacco Smoke
D.A. Savitz. 6. FISH (Fluorescence In Situ Hybridization) to Detect Effects of Smoking, Caffeine, and Alcohol on Human Sperm Chromosomes
W.A. Robbins. Markers of Sperm Damage and Germ Line Genotoxicity. 7. Sperm Nuclear DNA Damage in the Human
D. Sakkas, et at. 8. The Human Spermtozoon: Not Waving but Drowning
J R. Aitken, D. Sawyer. 9. Model Systems for Studying Germ Cell Mutagens: From Flies to Mammals
E.W. Vogel, M.J.M. Nivard. 10. Germline Mutation Induction at Mouse and Human Tandem Repeat DNA Loci
Y.E. Dubrova. 11. PAINT/DAPI Analysis of Mouse Zygotes to Detect Paternally Transmitted Chromosomal Aberrations
F. Marchetti, A.J. Wyrobek. Exposures and Effects: Causes of Cancer Consequences of Treatment. 12. Paternal Occupation and Childhood Cancer
A.F. Olshan, E.van Wijngaarten. 13. Radiation and Malformations in a Murine Model
W.-U. Muller. 14. Mechanisms of Action of Cyclophosphamide as a Male-Mediated Developmental Toxicant
B. Robaire, B.F. Hales. 15.Chromosome Abnormalities in Human Sperm
R.H. Martin. Pregnancy Outcome. 16. Distinguishing Between Fertilization Failure and Early Pregnancy Loss When Identifying Male-Mediated Adverse Pregnancy Outcomes
S.D. Perrault. 17. ICSI, Male Pronuclear Remodeling and Cell Cycle Checkpoints
L. Hewitson, et al. 18. Increased Incidence of Malformations in the Offspring of Male Mice Prenatally Exposed to Synthetic Estrogens
T. Nagao, et al. Strategies for Prevention. 19. Implications of Research in Male-Mediated Developmental Toxicity to Clinical Councellors, Regulators, and Occupational Safety Officers
J.M. Friedman. 20. Restoration of Spermatogenesis after Exposure to Toxicants: Genetic Implications
M.L. Meistrich, et al. Future Directions. 21. Epigenetics: Role of Germ Cell Imprinting
M.S. Bartolomei. 22. Efficiency and Safety of Animal Cloning
R. Yanagimachi. Workshop Reports. 23. Integrating New Tests of Sperm Genetic Integrity into Semen Analysis: Breakout Group Discussion
S.D. Perreault, et al. 24. Risk Assessment
A.F. Olshan, et al. 25. Study Designs for the Assessment of Male Mediated Developmental Toxicity
B.F. Hales, D.C. Cyr. 26. Translational Research in Male Mediated Developmental Toxicity
J.M. Trasler. Author Index. Subject Index.