This work contains a collection of review articles, each of which examines a single area of clinical importance, looking at what our understanding was, how it has changed and where it is leading. It offers advice on how to intergrate each advance into practice.

Evaluation of the potentially immunodeficient patient
treatment and prevention of opportunistic infections in patients with HIV infection
helicobacter pylori
infections associated with international travels
hyperparathyroidism and other hypercalcemic disorders
subclinical hypothyroidism - epidemiology, diagnosis and significance
evaluation and management of severe hyponatremia
new concepts in the pathogenesis of diabetes mellitus
adequacy of treatment for end-stage renal disease in the US
atrial fibrillation
neurocardiogenic syncope
challenges posed by the adult patient with congenital heart disease
lung transplantation - implications for the general internist
the genetic basis of colorectal cancer risk
melanoma - epidemiology, pathogenesis and new modes of treatment
systemic complications of non-steroidal anti-inflammatory drug use
current perspectives on the use of intervenous immunoglobulin
current status of immunology for allergies and anaphylactic reactions.