Focusing on subjects in modern human genetics and medicine, this volume considers the potential effectiveness and consequences of gene therapy on subjects over time. It discusses research on Gaucher's disease, the first disorder to demonstrate the clinical benefits of enzyme replacement therapy.

Disease-related genes will be falling from the skies faster than we can understand them, and mechanisms responsible for the pathogenesis of disease will be illuminated more quickly and readily than ever before."With comprehensive and timely reviews, "Advances in Genetics" incorporating Molecular Genetic Medicine offers with every volume further insight into this expanding field of medicine, supplementing the continued expert coverage of all other areas of genetics pioneered by "Advances in Genetics". It presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment. It chronicles the continuing explosion of knowledge in molecular genetic medicine by highlighting current approaches to understanding human illness. It documents the revolution in human and molecular genetics leading to a new field of medicine. Volume 32 marks new collaboration with Associate Editors Dr. Theodore Friedmann and Dr. Francesco Giannelli.

J.C. Hall and J.C. Dunlap, Foreword. T. Friedmann and F. Giannelli, Preface. F.D. Ledley, After Gene Therapy: Issues in Long-Term Clinical Follow-Up and Care. E. Beutler, Gaucher Disease. T.S. Pillay,W.J. Langlois, and J.M. Olefsky, The Genetics of Non-insulin-Dependent Diabetes Mellitus. P.M. Green, J.A. Naylor, and F. Giannelli, The Hemophilias. T.P. Knecht and C.K. Glass, The Influence of Molecular Biology on our Understanding of Lipoprotein Metabolism and the Pathobiology of Atherosclerosis. R.C. Eisensmith and S.L.C. Woo, Molecular Genetics of Phenylketonuria: From Molecular Anthropology to Gene Therapy. N.J. Royle, The Proterminal Regions and Telomeres of Human Chromosomes. References. Subject Index.