Part of "Advances in Developmental Biology and Biochemistry" series, this volume consists of five chapters that review specific aspects of fly and mammalian development. It also discusses various aspects of Mullerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to studies of the MIS gene in transgenic animals.

Volume 4 of "Advances in Developmental Biology and Biochemistry" consists of five chapters that review specific aspects of fly and mammalian development. In Chapter 1, Y. Mishina and R. Behringer discuss various aspects of Mullerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to recent studies of the MIS gene in transgenic and knock-out animals. In Chapter 2, C. Rushlow and S. Roth discuss the role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. In Chapter 3, M. Yip and H. Lipshitz discuss the terminal (asegmental termini) gene hierarchy of Drosophila and the genetic control of tissue specification and morphogenesis. In Chapter 4, R. Bachvarova discusses induction of mesoderm and the origin of anterior-posterior polarity in the mouse embryo, using the frog embryo as a paradigm. In Chapter 5, P. Vogt discusses human Y chromosome function in male germ cell development.

Contents. List of Contributors. Preface (P.M. Wassarman). The In Vivo Function of Mullerian-Inhibiting Substance During Mammalian Sexual Development (Y. Mishina and R.R. Behringer). The Role of the dpp-Group Genes in Dorsoventral Patterning of the Drosophila Embryo (C.Rushlow and S. Roth). The Terminal Gene Hierarchy of Drosophila and the Genetic Control of Tissue Specification and Morphogenesis (M.L.R. Yip and H.D. Lipshitz). Anterior-Posterior Polarization and Mesoderm Inducing Factors in the Pregastrula Mouse Embryo: Comparison to Chick and Frog Embryos (R.F. Bachvarova). Human Y Chromosome Function in Male Germ Cell Development (P.H. Vogt). Index.