PART 1. HOW GENOMES ARE MAPPED AND SEQUENCED. What is a genome. Mapping genomes by genetic techniques. Mapping
genomes by physical techniques. Sequencing genomes. PART 2. UNDERSTANDING A GENOME SEQUENCE. Locating genes in
DNA sequencing. Determining the function of a gene. Comparative genomics. Studying the transcriptome and proteome. PART 3. GENOME ANATOMIES. The physical organization of the eukaryotic nuclear genome. The genetic organization of the eukaryotic nuclear genome. Repetative DNA in the eukaryotic nuclear genome. Organelle genomes. The genomes of the bacteria. Genomes of the archaea. The genomes of viruses. PART 4. HOW RNA IS SYNTHESIZED. The
role of DNA. The role of DNA-binding proteins
accessing
the genome. Assembly of the transcription initiation complex. Synthesis and processing of RNA. PART 5. HOW THE
PROTEOME IS SYNTHESIZED. The role of tRNA. Ribosomes and translation of mRNA. Protein folding and post-translational modifications. PART 6. HOW GENOME ACTIVITY IS REGULATED. The role of chromatin structure. Regulation of transcriptional initiation. Regulation of RNA synthesis and processing. Regulation of proteome synthesis. The role of signalling pathways. Genome regulation and development. Cancer. PART 7. HOW GENOMES REPLICATE AND EVOLVE. Genome replication. Mutation. Recombination. Patterns of genome evolution. Molecular phylogenetics.