Provides physicians and scientists with guidance to the devastating diseases of the adrenals that are often difficult to diagnose and treat. This book includes reviews of disturbances in cortisol homeostasis, and concepts regarding adrenal tumors and hereditary adrenal diseases.

In "Adrenal Disorders", a panel of distinguished physicians and researchers select the most relevant new findings and integrate them into the existing body of clinical knowledge on adrenal pathologies. The book includes important reviews of disturbances in cortisol homeostasis, and new concepts regarding adrenal tumors and hereditary adrenal diseases. Also discussed are mineralocorticoids and the syndromes of mineralocortoid excess and aldosterone synthase deficiency. Authoritative and insightful, "Adrenal Disorders" provides physicians and scientists with a comprehensive, state-of-the-art practical guide to the devastating diseases of the adrenals that are so often difficult to diagnose and treat.

PART I. THE ADRENAL GLAND: SIOLOGY
Ontogeny of the Hypothalamo-Pituitary-Adrenal Axis
Adrenal Organogenesis and Steroidogenesis: e of Nuclear Receptor Steroidogenic Factor-1, Dax-1 and Estrogen Receptor
Reappraisal of Adrenal Zonation Theories Based on the Differential Regulation of Cortical Cell Proliferation and Apoptosis
Pharmacology of Glucocorticoids: Overview
Glucocorticoid Catabolism and the 11Beta-Hydroxysteroid Dehydrogenase System
Structure, Function, and Regulated Expression of the Steroidogenic Acute Regulatory Protein (StAR): ecular Insights into the Acute Steroidogenic Response of the Gonads and Adrenals
Regulation of Adrenocortical Function by the Sympathoadrenal System: siology and Pathology
Interleukin (IL)-1 Family of Cytokines and Cortocotropin-Releasing Hormone (CRH) in the Adrenal Gland
PART II. THE ADRENAL GLAND: HOPHYSIOLOGY
Overview of Hyper- and Hypocortisolism
ACTH Resistance Syndromes
Syndromes of Ectopic ACTH Secretion
Clinical Diagnosis and Presentations of Cushing's Syndromes
The Desmopressin Test: ew Tool in the Functional Evaluation of the Pituitary-Adrenal Axis in Patients with Cushing's Syndromes
PseudoCushing Syndromes
Adrenocortical Tumors and Oncogenes
Management of Adrenal Cancer
Adrenal Incidentalomas
Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency)
Congenital Adrenal Hyperplasia (11-Hydroxylase Deficiency)
Microconodular Adrenal Disease and the Syndrome of Myxomas
Spotty Skin Pigmentation and Endocrine
Congenital Lipoid Adrenal Hyperplasia
Congenital Adrenal Hypoplasia
HPA Axis and HIV Infection
Hypothalamic-Pituitary-Adrenal Axis and Obesity
Aldosterone Synthase Deficiency
Mineralocorticoid Excess Syndromes
Pheochromocytoma: gress in Diagnosis, Therapy, and Genetis