After three volumes on adenoviruses in 1995, the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.

After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.

Part 1: Virion and structure.- Molecular evolution of adenoviruses.- Novel partner proteins of adenovirus penton.- Structural studies on adenoviruses.- Part 2: Viral replication.- The multifunctional role of E1A in the transcriptional regulation of CREB/CBP-dependent target genes.- Mechanisms of adenovirus DNA replication.- Regulation of adenovirus packaging.- Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP.- The structure and function of the major late promoter.- Part 3: Host-cell interactions.- Remodeling of the host-cell RNA splicing machinery during an adenovirus infection.- Regulation of mRNA production by the adenoviral E1B 55 kDa and E4 ORF6 proteins.- Adenovirus interaction with its cellular receptor CAR.- Transactivation of the human cdc2 promoter by adenovirus E1A.- Models and vectors in virus-host interactions.- Abortive infection of hamster cells by adenovirus type 12.- Subject index.