Considers advances in the understanding and treatment of chemical dependence. Synthesizing basic and clinical research on cocaine, nicotine, cannabis, opiates and alcohol, the contributors show how insights into the mechanisms of the action of these drugs have improved treatment strategies.

This volume highlights the most significant advances in the understanding and treatment of chemical dependence. Synthesizing basic and clinical research on cocaine, nicotine, cannabis, opiates, and alcohol, the contributors attempt to show how insights into the mechanisms of action of these drugs and the neural pathways of reward have been translated into improved treatment strategies. Key issues examined include brain mechanisms of drug-induced reinforcement, neuroendocrine systems involved in reinforcement, the role of drug receptors and endogenous ligands in addiction, the relationship of psychopathology to addiction, the neurological complications of substance abuse, the rationale for maintenance pharmacotherapy of opiate dependence, and the relative efficacy of treatments for dependence on alcohol and other drugs.