Elucidation of adaptive physiological mechanisms in migraine can rationalise important epidemiological, clinical, and pharmacological features and sow the seeds for evolution of an integrative synthesis which process, in turn, might herald the creation of a comprehensive thought framework and research vision for migraine.

Magnesium depletion, platelet activation, peripheral alterations in serotonin and catecholamine metabolism, hyper-responsiveness of brain noradrenergic, serotonergic, vasopressinergic, and dopaminergic systems, parasympathetic nevous system activation, pupillary miosis, and cutaneous allodynia probably represent some of the secondary adaptive physiological mechanisms operative in migraine.A critical or central role for brain neuronal involvement in migraine pathogenesis appears unikely as established migraine preventive agents like atenolol, nadolol, and verapamil do not readily cross the intact blood-brain barrier or influence brain neuronal function. Antidepressants, including amitriptyline, induce brain noradrenergic and serotonergic hyperfunction, rendering highly unlikely that such brain states underlie migraine. Elucidation of adaptive physiological mechanisms in migraine can rationalise important epidemiological, clinical, and pharmacological features and sow the seeds for evolution of an integrative synthesis which process, in turn, might herald the creation of a comprehensive thought framework and research vision for migraine.

Preface
Background: What Ails Migraine Research
Quest for A New Research Paradigm for Migraine: 'Why' and 'How'
Nausea/Vomiting-Vasopressin Nexus in Migraine
Magnesium Depletion, Migraine, and Cellular Adaptation
Stress, Brain Autonomic Function, BBB, and Migraine
Pupil, Eyelid, and Migraine
Prolactin, Melatonin, Stress and Migraine
Evoked Potentials, Migraine and Arousal
The Platelet-Serotonin-Brain Neuronal Connection: Milestone or Millstone
Conclusion
Index.