Acute toxicology testing provides defense against potentially dangerous chemicals. This book serves as a guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for the common test designs and reviews their development and objectives.

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. "Acute Toxicology Testing, Second Edition" will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Its key features include: over 100 tables summarizing and interpreting results; complete coverage of all major test designs and their limitations and advantages; and current status of alternative test designs and models.

Introduction. Acute Toxicology Program: Study Design and Development. Tests for Dermal Irritation and Corrosion. Ocular Irritation Testing. Dermal Sensitization. Photosensitization/Phototoxicity. Lethality Testing. Safety Considerations for the Administration of Agents By the Parenteral Routes. Acute Systemic Toxicity Tests. Routes, Formulations, And Vehicles. Considerations Specific to Animal Test Models. Statistical Analysis for Acute Toxicology. Acute Inhalation. Problems and Issues. Appendices. Subject Index.