Provides the information necessary to understand, diagnose, and treat acute renal failure (ARF). This book describes progress in the understanding of the pathophysiology of ARF, and also emphasizes the clinical spectrum and management of the different disease processes causing ARF.

The most common reason for a renal consult in a hospitalized patient is acute renal failure (ARF). This new companion book to Brenner and Rector's "The Kidney" provides the reader with the complete information necessary to understand, diagnose, and treat this serious and challenging condition. The first part of the book describes recent progress in the understanding of the pathophysiology of ARF, explaining the tremendous strides in the molecular and cellular aspects of cell injury and recovery. The remainder (and majority) of the text emphasizes the clinical spectrum and management of the different disease processes causing ARF. In these chapters, ARF is discussed in terms of its many associated disease processes such as pigment nephropathy, burns, infectious disease, and gastrointestinal and liver disease. This format allows for rapid referral and an in-depth understanding of all clinical aspects of ARF, including its most important aspect of management: to prevent the disease from becoming chronic, ultimately leading to dialysis and then transplantation.

I. The Pathophysiology of Acute Renal Failure 1. Morphologic basis of ARF Loraine C. Racusen 2. Vascular alterations in ARF: establishment and maintenance John Conger 3. Cytoskeletal alterations as a basis of cellular injury in ARF Bruce Molitoris 4. Heat shock proteins: role in prevention and recovery from ARF Norm Siegel 5. Growth factors and signal transduction in response to ARF Joe Bonventre 6. Inflammatory response and its consequences in ARF Robert Starr 7. DNA damage and repair in ARF Sudir Shah 8. Terminal pathways in cell death Wil Lieberthal 9. The role of iron and heme oxygenase in ARF Karl Nath
II. The Clinical Spectrum of Acute Renal Failure 1. Clinical and laboratory diagnosis Robert J. Anderson 2. Metabolic and electrolyte disturbances E.A. Burdman 3. Imaging techniques in ARF Richard Clark 4. Surgical and post-traumatic ARF Ori S. Better, Glen M. Chertow 5. ARF in pregnancy Susan H. Hou 6. Pigment nephropathy James P. Knochel, Karl Nath 7. ARF with cardiovascular disease J. Fort 8. ARF in liver disease Murray Epstein 9. ARF in rheumatologic disease P. Nachman, G. Eknoyan 10. ARF in burns E.M. Abdel-Rahman 11. Infectious disease Louis Yu, John Dillon 12. Malignancy David J. Salant, Kaml F. Badr 13. Transplantation Bryan Myers, Richard Zager 14. ARF associated with diagnostic and therapeutic agents Christiane M. Erley, Marc DeBroe, Thomas DuBose, Jr., J.H. Turney 15. ARF with occupational and environmental settings Patricia Mueller, Geoff Dugin 16. ARF in natural disasters Norbert Lameire
III. Management of Acute Renal Failure 1. Patterns of recovery, residual injury, mortality rates William F. Finn 2. Nutritional support in patients with ARF Joel D. Kopple 3. Dialysis Claudio Ronco, Ravi H. Mehta, Raymond Hakim 4. Predictive factors and scoring F. Liano 5. Multiple organ system failure D. Kleinknecht