The knowledge base about acute myocardial infarction continues to accrue rapidly with information about pathophysiology, epidemiology, reperfusion therapy. There are however areas where substantial more investigation is required. This title explores these areas and define what works, what has not worked, and what may work in the future.

In this issue of the "Medical Clinics of North America", Guest Edited by luminaries David Holmes and Mandeep Singh, we explore these areas and define what works, what has not worked, and what may work in the future.